The majority of long-haul truck drivers are affected by fatigue. Notably, fatigue impacts not only quality of life, but the risk for human error, thus impacting the safety of our nation’s roads. In 2017, 400,000 trucking accidents occurred with the top driver impairment identified as being “asleep or fatigued.” Yet, the current scientific literature reflects different understandings of the concept of fatigue, hindering synchronized measurement and efforts toward its alleviation. The purpose of this work was to analyze the concept of fatigue in long-haul truck drivers using the Rodgers’ evolutionary method. The physical, cognitive, and emotional dimensions of fatigue are presented.